(19)

(11)

EP 1 608 359 A2

(12)

(88) Date of publication A3: 21.04.2005 (43) Date of publication: 28.12.2005 Bulletin 2005/52 (21) Application number: 04758803.3 (22) Date of filing: 02.04.2004

(51) International Patent Classification (IPC)7: A61K 31/335 (86) International application number: PCT/US2004/010230 (87) International publication number: WO 2004/089291 (21.10.2004 Gazette 2004/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 03.04.2003 US 460827 P (71) Applicants: AU, Jessie, L.-S. Columbus, OH 43235 (US) Wientjes, M. Guillaume Columbus, OH 43210 (US)	(72) Inventors: AU, Jessie, L.-S. Columbus, OH 43235 (US) Wientjes, M. Guillaume Columbus, OH 43210 (US) (74) Representative: Schmitz, Jean-Marie et al Dennemeyer & Associates Sàrl P.O. Box 1502 1015 Luxembourg 1015 Luxembourg (LU)