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EP 1 608 639 A2

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(88) Date of publication A3: 11.11.2004 (43) Date of publication: 28.12.2005 Bulletin 2005/52 (21) Application number: 04716166.6 (22) Date of filing: 01.03.2004

(51) International Patent Classification (IPC)7: C07D 401/12, C07D 417/12, C07D 413/12, C07D 213/89, C07D 405/12, C07D 409/12, C07D 405/14, C07D 401/14, A61K 31/443, A61K 31/4433, A61K 31/4436, A61K 31/4439, A61K 31/444, A61P 35/00 (86) International application number: PCT/US2004/006287 (87) International publication number: WO 2004/078748 (16.09.2004 Gazette 2004/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 28.02.2003 US 450348 P (71) Applicant: Bayer Pharmaceuticals Corporation West Haven, CT 06516-4175 (US)

(72) Inventors: DUMAS, Jacques Bethany, CT 06524 (US) BOYER, Stephen D-40721 Hilden (DE) VERMA, Sharad New Haven, CT 06519 (US) ADNANE, Lila Madison, CT 06443 (US) CHEN, Yuanwei North Haven, CT 06473 (US) LEE, Wendy Hamden, CT 06518 (US) PHILLIPS, Barton New Haven, CT 06511 (US) SMITH, Roger, A. Madison, CT 06443 (US) SCOTT, William, J. Guilford, CT 06437 (US) BURKE, Jennifer New Haven, CT 06511 (US) CHEN, Jianqing New Haven, CT 06515 (US) CHEN, Zhi Hamden, CT 06514 (US) FAN, Jianmei Hamden, CT 06518 (US) MIRANDA, Karl North Haven,CT 06473 (US) RAUDENBUSH, Brian Charlton, MA 01507 (US) REDMAN, Aniko Derby, CT 06418 (US) SHAO, Jianxing Cheshire, CT 06410 (US) SU, Ning Hamden, CT 06518 (US) WANG, Gan Wallingford, CT 06492 (US) ZHU, Qingming West Haven, CT 06516 (US) (74) Representative: Ziebig, Marlene et al Anwaltskanzlei Gulde Hengelhaupt Ziebig & Schneider Wallstrasse 58/59 D-10179 Berlin D-10179 Berlin (DE)