(19)
(11) EP 1 608 655 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.10.2008 Bulletin 2008/42

(45) Mention of the grant of the patent:
16.07.2008 Bulletin 2008/29

(21) Application number: 04741432.1

(22) Date of filing: 22.03.2004
(51) International Patent Classification (IPC): 
C07D 487/04(2006.01)
 A61K 31/4188(2006.01)
(86) International application number:
PCT/EP2004/050339
(87) International publication number:
WO 2004/085438 (07.10.2004 Gazette 2004/41)

(54)

PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS

PYRROLOIMIDAZOLDERIVATE ,VERFAHERN ZU IHRER HERSTELLUNG, DIESE ENTHALTENDE ZUSAMMENSETZUNGEN, UND IHRE VERWENDUNG ALS NOOTROPIKA

COMPOSES PRESENTANT UNE ACTION NOOTROPIQUE, LEUR PREPARATION, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET LEUR UTILISATION

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 24.03.2003 IT MI20030573

(43) Date of publication of application:
28.12.2005 Bulletin 2005/52

(73) Proprietor: BRANE DISCOVERY SRL IN LIQUIDAZIONE
20021 Baranzate (IT)

(72) Inventors:
  • FARINA, Carlo c/o NIKEM RESEARCH S.R.L.
    I-20021 BARANZATE DI BOLLATE (IT)
  • GAGLIARDI, Stefania c/o NIKEM RESEARCH S.R.L.
    I-20021 BARANZATE DI BOLLATE (IT)
  • PARINI, Carlo c/o NIKEM RESEARCH S.R.L.
    I-20021 BARANZATE DI BOLLATE (IT)
  • MARTINELLI, Marisa c/o NIKEM RESEARCH S.R.L.
    I-20021 BARANZATE DI BOLLATE (IT)
  • GHELARDINI, Carla; c/o Dipartimento di
    Mancini" Università di Firenze (IT)

(74) Representative: Gerli, Paolo et al
Notarbartolo & Gervasi S.p.A. Corso di Porta Vittoria, 9
20122 Milano
20122 Milano (IT)


(56) References cited: : 
EP-A- 0 174 136
WO-A-93/09120
 EP-A- 0 335 483
   
  • MARIO PINZA ET AL.: "Synthesis and Pharmacological Activity of a Series of Dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H, 6H)-diones, a Novel Class of Potent Cognition Enhancers" JOURNAL OF MEDICINAL CHEMISTRY., vol. 36, no. 26, 24 December 1993 (1993-12-24), pages 4214-4220, XP002295812 USAMERICAN CHEMICAL SOCIETY.
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).