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(11)

EP 1 610 775 A2

(12)

(88) Date of publication A3: 17.02.2005 (43) Date of publication: 04.01.2006 Bulletin 2006/01 (21) Application number: 04749626.0 (22) Date of filing: 01.04.2004

(51) International Patent Classification (IPC):  A61K 31/40(1985.01) A61K 31/54(1985.01) A61K 31/13(1985.01) A61P 9/12(2000.01) (86) International application number: PCT/US2004/010052 (87) International publication number: WO 2004/087132 (14.10.2004 Gazette 2004/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 01.04.2003 US 459563 P 01.04.2003 US 405076 (71) Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. Alachua, Florida 32615 (US) ABBOTT LABORATORIES Abbott Park, Illinois 60064-6050 (US)

(72) Inventors: PEPINE, Carl, J. Gainesville, FL 32608 (US) HANDBERG, Eileen, M. Gainesville, FL 32605 (US) COOPER-DEHOFF, Rhonda, M. Gainesville, FL 32653 (US) NABULSI, Azmi Barrington, IL 60010 (US) ALTMAN, Robert Wilmette, IL 60091 (US) DRAJESK, Jeff Burlington, WI 53105 (US) WILLIAMS, Laura Gurnee, IL 60031 (US) ZILLES, Peter, S. 68623 Lampertheim (DE) LEGLER, Udo, F. 76829 Landau/Pfalz (DE) (74) Representative: Ahner, Francis et al Cabinet Régimbeau 20, rue de Chazelles 75847 Paris cedex 17 75847 Paris cedex 17 (FR)