(19)

(11)

EP 1 611 236 A1

(12)

(43) Date of publication: 04.01.2006 Bulletin 2006/01 (21) Application number: 04721468.9 (22) Date of filing: 18.03.2004

(51) International Patent Classification (IPC):  C12N 9/64(1980.01) A61K 38/48(1995.01) (86) International application number: PCT/DK2004/000183 (87) International publication number: WO 2004/083421 (30.09.2004 Gazette 2004/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 18.03.2003 DK 200300413 26.03.2003 US 457809 P (71) Applicant: Novo Nordisk Health Care AG 8050 Zürich (CH)	(72) Inventors: KRARUP, Janus DK-2820 Gentofte (DK) PERSSON, Egon S-232 52 Akarp (SE)