(19)

(11)

EP 1 611 249 A1

(12)

(43) Date of publication: 04.01.2006 Bulletin 2006/01 (21) Application number: 03716922.4 (22) Date of filing: 31.03.2003

(51) International Patent Classification (IPC):  C12Q 1/68(1980.01) C12N 5/00(1980.01) C12N 15/63(1990.01) C07H 21/02(1974.07) C12P 19/34(1980.01) C12N 15/00(1980.01) A01N 43/04(1985.01) C07H 21/04(1974.07) (86) International application number: PCT/US2003/009808 (87) International publication number: WO 2004/097049 (11.11.2004 Gazette 2004/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (71) Applicant: ISIS PHARMACEUTICALS, INC. Carlsbad, CA 92008 (US)	(72) Inventor: CROOKE, Stanley, T. Carlsbad, CA 92009 (US) (74) Representative: Bassil, Nicholas Charles  Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)