(19)

(11)

EP 1 613 965 A2

(12)

(88) Date of publication A3: 03.03.2005 (43) Date of publication: 11.01.2006 Bulletin 2006/02 (21) Application number: 04775884.2 (22) Date of filing: 12.04.2004

(51) International Patent Classification (IPC):  G01N 33/569(1985.01) G01N 33/543(1985.01) G01N 33/558(1985.01) C12Q 1/06(1980.01) (86) International application number: PCT/US2004/011285 (87) International publication number: WO 2005/001475 (06.01.2005 Gazette 2005/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 10.04.2003 US 249452 10.04.2003 WO PCT/US03/11253 13.02.2004 US 544437 P 31.03.2004 US 557962 P (71) Applicants: Voorhees, Kent J. Golden, CO 80403 (US) Rees, John Golden, Colorado 80403 (US) Wheeler, John H. Boulder, Colorado 80301 (US)

(72) Inventors: Voorhees, Kent J. Golden, CO 80403 (US) Rees, John Golden, Colorado 80403 (US) Wheeler, John H. Boulder, Colorado 80301 (US) (74) Representative: Tönhardt, Marion  Forrester & Boehmert, Pettenkoferstrasse 20-22 80336 München 80336 München (DE)