(19)

(11)

EP 1 615 497 A2

(12)

(88) Date of publication A3: 14.04.2005 (43) Date of publication: 18.01.2006 Bulletin 2006/03 (21) Application number: 03723860.7 (22) Date of filing: 02.04.2003

(51) International Patent Classification (IPC):  A01N 1/00(1968.09) C12N 5/06(1990.01) A01N 1/02(1968.09) C12N 5/08(1990.01) (86) International application number: PCT/US2003/009819 (87) International publication number: WO 2004/096123 (11.11.2004 Gazette 2004/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (71) Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA Minneapolis, MN 55455 (US)	(72) Inventors: STEER, Clifford, J. St. Paul, MN 55116 (US) LOW, Walter, C. Shorewood, MN 55331 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)