(19)

(11)

EP 1 618 201 A1

(12)

(43) Date of publication: 25.01.2006 Bulletin 2006/04 (21) Application number: 04712943.2 (22) Date of filing: 19.02.2004

(51) International Patent Classification (IPC):  C12N 15/864(2000.01) C12N 5/10(1990.01) C07K 14/015(1995.01) A61K 48/00(1990.01) (86) International application number: PCT/US2004/005205 (87) International publication number: WO 2004/099423 (18.11.2004 Gazette 2004/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 01.05.2003 WO PCT/US03/13583 (71) Applicant: University of Florida Research Foundation, Inc. Gainesville, FL 32611-5500 (US)	(72) Inventors: WARRINGTON, Kenneth H. Gainesville, FL 32607 (US) OPIE, Shaun, R. Scottsdale, AZ 85258 (US) MUZYCZKA, Nicholas Gainesville, FL 32608 (US) (74) Representative: Glawe, Delfs, Moll  Patentanwälte Rothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)