(19)

(11)

EP 1 620 424 A2

(12)

(88) Date of publication A3: 10.03.2005 (43) Date of publication: 01.02.2006 Bulletin 2006/05 (21) Application number: 04703977.1 (22) Date of filing: 21.01.2004

(51) International Patent Classification (IPC):  C07D 333/22(1985.01) A61K 31/38(1985.01) (86) International application number: PCT/US2004/001304 (87) International publication number: WO 2004/067481 (12.08.2004 Gazette 2004/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (30) Priority: 21.01.2003 US 453720 P (71) Applicant: Flexitral Inc. Chantilly, VA 20151 (US)	(72) Inventor: TURIN, Luca London NW1 7NB (GB) (74) Representative: Crowhurst, Charlotte Waveney et al Eric Potter Clarkson Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)