(19)

(11)

EP 1 620 546 A2

(12)

(43) Date of publication: 01.02.2006 Bulletin 2006/05 (21) Application number: 04760140.6 (22) Date of filing: 21.04.2004

(51) International Patent Classification (IPC):  C12N 1/00(1980.01) (86) International application number: PCT/US2004/012494 (87) International publication number: WO 2004/094611 (04.11.2004 Gazette 2004/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 21.04.2003 US 464227 P 20.01.2004 WO PCT/US20/04001375 (71) Applicant: The University of Massachusetts Boston, MA 02108-3107 (US)	(72) Inventor: ROBL, James, M. Sioux Falls, SD 57106 (US) (74) Representative: Daniels, Jeffrey Nicholas et al Page White & Farrer 54 Doughty Street London WC1N 2LS London WC1N 2LS (GB)