(19)

(11)

EP 1 620 562 A2

(12)

(43) Date of publication: 01.02.2006 Bulletin 2006/05 (21) Application number: 04702134.0 (22) Date of filing: 14.01.2004

(51) International Patent Classification (IPC):  C12Q 1/00(1980.01) (86) International application number: PCT/US2004/000819 (87) International publication number: WO 2004/094655 (04.11.2004 Gazette 2004/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 11.04.2003 WO PCT/US03/11393 (71) Applicant: Trustees of Boston University Boston, MA 02215 (US)	(72) Inventors: GILCHREST, Barbara, A. Brookline, MA 02146 (US) ELLER, Mark Boston, MA 02116 (US) (74) Representative: Rasser, Jacobus Cornelis et al Howrey Simon Arnold & White P.O. Box 94361 1090 GJ Amsterdam 1090 GJ Amsterdam (NL)