(19)

(11)

EP 1 620 575 A2

(12)

(88) Date of publication A3: 23.12.2004 (43) Date of publication: 01.02.2006 Bulletin 2006/05 (21) Application number: 04760623.1 (22) Date of filing: 30.04.2004

(51) International Patent Classification (IPC):  C12Q 1/68(1980.01) C07H 21/04(1974.07) C12P 19/34(1980.01) (86) International application number: PCT/US2004/013222 (87) International publication number: WO 2004/099755 (18.11.2004 Gazette 2004/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 02.05.2003 US 429293 (71) Applicant: Geneohm Sciences, Inc. San Diego, CA 92121 (US)	(72) Inventors: CROTHERS, Donald, M. Northford, CT 06472 (US) HOLMLIN, R., Erik San Diego, CA 92101 (US) SHI, Chunnian San Diego, CA 92130 (US) (74) Representative: Raynor, Simon Mark  Urquhart-Dykes & Lord LLP Midsummer House, 413 Midsummer Boulevard Central Milton Keynes MK9 3BN Central Milton Keynes MK9 3BN (GB)