(19)

(11)

EP 1 620 716 A2

(12)

(88) Date of publication A3: 14.07.2005 (43) Date of publication: 01.02.2006 Bulletin 2006/05 (21) Application number: 04785792.5 (22) Date of filing: 06.05.2004

(51) International Patent Classification (IPC):  G01N 23/221(1974.07) (86) International application number: PCT/US2004/013902 (87) International publication number: WO 2005/003718 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 06.05.2003 US 468376 P (71) Applicant: The Trustees of Columbia University in the City of New York New York, NY 10027 (US)	(72) Inventor: HAILEY, Charles New York, NY 10027 (US) (74) Representative: Lawrence, John  Barker Brettell, 138 Hagley Road, Edgbaston Birmingham B16 9PW Birmingham B16 9PW (GB)