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(11)

EP 1 622 684 A2

(12)

(43) Date of publication: 08.02.2006 Bulletin 2006/06 (21) Application number: 04775923.8 (22) Date of filing: 30.04.2004

(51) International Patent Classification (IPC):  A61P 1/00(2000.01) (86) International application number: PCT/US2004/013455 (87) International publication number: WO 2005/004988 (20.01.2005 Gazette 2005/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 01.05.2003 US 427211 01.05.2003 US 427212 04.08.2003 US 634114 08.03.2004 US 795535 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN Ann Arbor, Mi 48109-1280 (US)	(72) Inventors: GLICK, Gary, D. Ann Arbor, MI 48103 (US) OPIPARI, Anthony, W. Ann Arbor, MI 48103 (US) (74) Representative: Glawe, Delfs, Moll  Patent- und Rechtsanwälte, Rothenbaumchaussee 58 20148 Hamburg 20148 Hamburg (DE)