(19)
(11) EP 1 622 916 A2

(12)

(88) Date of publication A3:
24.03.2005

(43) Date of publication:
08.02.2006 Bulletin 2006/06

(21) Application number: 04750112.7

(22) Date of filing: 14.04.2004
(51) International Patent Classification (IPC): 
C07D 515/04(1985.01)
 A61K 31/44(1985.01)
(86) International application number:
PCT/US2004/011463
(87) International publication number:
WO 2004/094371 (04.11.2004 Gazette 2004/45)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
Designated Extension States:
LT LV

(30) Priority: 17.04.2003 US 463673 P

(71) Applicants:
  • Merck & Co., Inc.
    Rahway, New Jersey 07065-0907 (US)
  • MERCK SHARP & DOHME LTD.
    Hoddesdon, Hertfordshire EN11 9BU (GB)

(72) Inventors:
  • BUTORA, Gabor
    Rahway, New Jersey 07065-0907 (US)
  • GOBLE, Stephen, D.
    Rahway, New Jersey 07065-0907 (US)
  • PASTERNAK, Alexander
    Rahway, New Jersey 07065-0907 (US)
  • YANG, Lihu
    Rahway, New Jersey 07065-0907 (US)
  • ZHOU, Changyou
    Rahway, New Jersey 07065-0907 (US)
  • MOYES, Christopher, R.
    Hoddesdon Hertfordshire EN11 9BU (GB)

(74) Representative: Man, Jocelyn et al
Merck & Co.,Inc. European Patent Department Terlings Park Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY