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EP 1 623 026 A1

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(43) Date of publication: 08.02.2006 Bulletin 2006/06 (21) Application number: 04728609.1 (22) Date of filing: 21.04.2004

(51) International Patent Classification (IPC):  C12N 9/16(1980.01) G01N 33/68(1980.01) A61K 31/00(1985.01) (86) International application number: PCT/IB2004/001332 (87) International publication number: WO 2004/097010 (11.11.2004 Gazette 2004/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 01.05.2003 GB 0310058 (71) Applicants: Pfizer Limited Sandwich, Kent CT13 9NJ (GB) GB  PFIZER INC. New York, New York 10017 (US) AT BE BG CH CY CZ DE DK EE ES FI FR GR HU IE IT LU MC NL PL PT RO SE SI SK TR

(72) Inventors: BROWN, David, Graham Sandwich, Kent CT13 9NJ (GB) GROOM, Colin, Roger Sandwich, Kent CT13 9NJ (GB) HOPKINS, Andrew, Lee Sandwich, Kent CT13 9NJ (GB) JENKINS, Timothy, Mark Sandwich, Kent CT13 9NJ (GB) KAMP, Sarah, Helen Sandwich, Kent CT13 9NJ (GB) O'GARA, Margaret, Mary Sandwich, Kent CT13 9NJ (GB) RINGROSE, Heather, Joan Sandwich, Kent CT13 9NJ (GB) ROBINSON, Colin, Mark Sandwich, Kent CT13 9NJ (GB) TAYLOR, Wendy, Elaine Sandwich, Kent CT13 9NJ (GB) (74) Representative: Courgeon, Antoine et al Pfizer European Pharma Patent Department 23-25, avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)