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(11)

EP 1 625 138 A2

(12)

(88) Date of publication A3: 10.11.2005 (43) Date of publication: 15.02.2006 Bulletin 2006/07 (21) Application number: 04759940.2 (22) Date of filing: 16.04.2004

(51) International Patent Classification (IPC):  C07H 19/00(1974.07) C07H 21/02(1974.07) C07H 21/00(1974.07) C07H 21/04(1974.07) (86) International application number: PCT/US2004/011822 (87) International publication number: WO 2004/094345 (04.11.2004 Gazette 2004/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 17.04.2003 US 463772 P 25.04.2003 US 465802 P 25.04.2003 US 465665 P 09.05.2003 US 469612 P 08.08.2003 US 493986 P 11.08.2003 US 494597 P 26.09.2003 US 506341 P 09.10.2003 US 510246 P 10.10.2003 US 510318 P 07.11.2003 US 518453 P 08.03.2004 WO PCT/US20/04007070 05.04.2004 WO PCT/US20/04001586 09.04.2004 WO PCT/US20/04011255 (71) Applicant: Alnylam Pharmaceuticals Inc. Cambridge, MA 02139 (US)

(72) Inventor: MANOHARAN, Muthiah Weston, MA 02493 (US) (74) Representative: Ruffles, Graham Keith  Marks & Clerk 66-68 Hills Road Cambridge CB2 1LA Cambridge CB2 1LA (GB)