(19)

(11)

EP 1 625 162 A2

(12)

(88) Date of publication A3: 28.04.2005 (43) Date of publication: 15.02.2006 Bulletin 2006/07 (21) Application number: 04760728.8 (22) Date of filing: 06.05.2004

(51) International Patent Classification (IPC):  C07K 16/14(1995.01) C12N 5/10(1990.01) C12N 5/20(1990.01) C12N 15/13(1990.01) (86) International application number: PCT/US2004/014276 (87) International publication number: WO 2004/099251 (18.11.2004 Gazette 2004/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 06.05.2003 US 468475 P 30.05.2003 US 474530 P 23.03.2004 US 555540 P (71) Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY Bronx New York 10461 (US)	(72) Inventors: PIROFSKI, Liise-anne New York, NY 10128 (US) MAITTA, Robert, W. Bronx, NY 10461 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)