(19)

(11)

EP 1 626 717 A2

(12)

(88) Date of publication A3: 17.03.2005 (43) Date of publication: 22.02.2006 Bulletin 2006/08 (21) Application number: 04751318.9 (22) Date of filing: 05.05.2004

(51) International Patent Classification (IPC):  A61K 31/415(1985.01) C07D 235/04(1985.01) (86) International application number: PCT/US2004/013874 (87) International publication number: WO 2004/100875 (25.11.2004 Gazette 2004/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: LT LV (30) Priority: 09.05.2003 US 469332 P (71) Applicant: Merck & Co., Inc. Rahway, New Jersey 07065-0907 (US)

(72) Inventors: PARMEE, Emma, R. Rahway, New Jersey 07065-0907 (US) KIM, Ronald, M. Rahway, New Jersey 07065-0907 (US) LIANG, Rui Rahway, New Jersey 07065-0907 (US) CHANG, Jiang Rahway, New Jersey 07065-0907 (US) ROUSE, Elizabeth Ashley Rahway, New Jersey 07065-0907 (US) CHAPMAN, Kevin, T. Rahway, New Jersey 07065-0907 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)