(19)

(11)

EP 1 627 066 A2

(12)

(88) Date of publication A3: 28.04.2005 (43) Date of publication: 22.02.2006 Bulletin 2006/08 (21) Application number: 04739205.5 (22) Date of filing: 13.05.2004

(51) International Patent Classification (IPC):  C12N 15/55(1990.01) C12Q 1/68(1980.01) G01N 33/573(1985.01) C12N 9/16(1980.01) (86) International application number: PCT/EP2004/005190 (87) International publication number: WO 2004/101779 (25.11.2004 Gazette 2004/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 16.05.2003 WO PCT/EP03/05319 (71) Applicant: JANSSEN PHARMACEUTICA N.V. 2340 Beerse (BE)	(72) Inventors: BALEMANS, Wendy, Mia, Albert 2920 Kalmthout (BE) MOECHARS, Diederik, Willem, Elisabeth 2340 Beerse (BE) STECKLER, Thomas, Horst, Wolfgang 2340 Beerse (BE) CRYNS, Kim 2340 Beerse (BE)