| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
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| (30) |
Priority: |
15.05.2003 US 470681 P
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| (43) |
Date of publication of application: |
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01.03.2006 Bulletin 2006/09 |
| (60) |
Divisional application: |
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10179747.0 / 2266606 |
| (73) |
Proprietors: |
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- Genentech, Inc.
South San Francisco CA 94080-4990 (US)
- MEDINNOVA AS
0027 Oslo (NO)
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| (72) |
Inventors: |
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- FUNG, Sek Chung
Houston, TX 77025 (US)
- MOLLNES, Tom Eirik
N-8013 Bodø (NO)
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| (74) |
Representative: Evenson, Jane Harriet et al |
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Mathys & Squire LLP
120 Holborn
London EC1N 2SQ
London EC1N 2SQ (GB) |
| (56) |
References cited: :
WO-A-01/15731
US-A1- 2002 034 509
US-B1- 6 297 049
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WO-A-03/015819
US-A1- 2002 044 929
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- MOLLNES TOM EIRIK ET AL: "Essential role of the C5a receptor in E. coli-induced oxidative
burst and phagocytosis revealed by a novel lepirudin-based human whole blood model
of inflammation" BLOOD, vol. 100, no. 5, 1 September 2002 (2002-09-01), pages 1869-1877,
XP002440770 ISSN: 0006-4971
- LETURCQ DIDIER J ET AL: "Antibodies against CD14 protect primates from endotoxin-induced
shock" JOURNAL OF CLINICAL INVESTIGATION, vol. 98, no. 7, 1996, pages 1533-1538, XP002440771
ISSN: 0021-9738
- HUBER-LANG MARKUS S ET AL: "Protection of innate immunity by C5aR antagonist in septic
mice" FASEB JOURNAL, vol. 16, no. 12, October 2002 (2002-10), pages 1567-1574, XP002440772
ISSN: 0892-6638
- MOLLNES ET AL.: 'Inhibition of endotoxin-induced oxidative burst by the C3 binding
peptide compstatin in a novel whole blood model of inflammation' IMMUNOPHARMACOLOGY
vol. 49, no. 1-2, August 2000, page 62, XP002985846
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