(19)

(11)

EP 1 628 637 A2

(12)

(88) Date of publication A3: 15.09.2005 (43) Date of publication: 01.03.2006 Bulletin 2006/09 (21) Application number: 04753731.1 (22) Date of filing: 27.05.2004

(51) International Patent Classification (IPC):  A61K 9/127(1990.01) A61K 9/72(1974.07) (86) International application number: PCT/US2004/016962 (87) International publication number: WO 2004/110493 (23.12.2004 Gazette 2004/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 30.05.2003 US 475080 P (71) Applicant: ALZA CORPORATION Mountain View, CA 94039-7210 (US)	(72) Inventors: WONG, Frances, M., P. Redwood City, CA 94065 (US) DAS, Anuk Wayne, PA 19087 (US) SEIDEMAN, Jonathan Southampton, PA 18966 (US) GUO, Luke Lafayette, CA 94549 (US) HUANG, Anthony Saratoga, CA 95070 (US) (74) Representative: Williams, Paul Edwin et al Ablett & Stebbing Caparo House 101-103 Baker Street London W1U 6FQ London W1U 6FQ (GB)