(19)
(11) EP 1 631 260 A2

(12)

(88) Date of publication A3:
20.01.2005

(43) Date of publication:
08.03.2006 Bulletin 2006/10

(21) Application number: 04715190.7

(22) Date of filing: 26.02.2004
(51) International Patent Classification (IPC): 
A61K 9/14(1974.07)
C07D 233/00(1985.01)
 C07C 233/00(1990.01)
A61K 31/00(1985.01)
(86) International application number:
PCT/US2004/006288
(87) International publication number:
WO 2004/078163 (16.09.2004 Gazette 2004/38)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 28.02.2003 US 451213 P
03.03.2003 WO PCT/US03/06662
18.03.2003 US 456027 P
18.04.2003 US 463962 P
30.05.2003 US 449307
20.06.2003 WO PCT/US03/19574
20.06.2003 US 601092
11.07.2003 US 487064 P
04.09.2003 WO PCT/US03/27772
11.09.2003 US 660202
02.10.2003 US 508208 P
24.12.2003 WO PCT/US03/41273
06.02.2004 US 542752 P

(71) Applicants:
  • Transform Pharmaceuticals, Inc.
    Lexington, MA 02421 (US)
  • UNIVERSITY OF SOUTH FLORIDA
    Tampa, FL 33620-7900 (US)
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Ann Arbor, MI 48109-1280 (US)

(72) Inventors:
  • ALMARSSON, Örn
    Shrewsbury, MA 01545 (US)
  • HICKEY, Magali, Bourghol
    Medford, MA 02155 (US)
  • PETERSON, Matthew
    Framingham, MA 01701 (US)
  • MOULTON, Brian
    Providence, RI 02912 (US)
  • RODRIGUEZ-HORNEDO, Nair
    Ann Arbor, MI 48103 (US)
  • ZAWOROTKO, Michael, J.
    Tampa FL 33647 (US)

(74) Representative: Lucas, Brian Ronald et al
Lucas & Co. 135 Westhall Road
Warlingham Surrey CR6 9HJ
Warlingham Surrey CR6 9HJ (GB)

   


(54) PHARMACEUTICAL CO-CRYSTAL COMPOSITIONS OF DRUGS SUCH AS CARBAMAZEPINE, CELECOXIB, OLANZAPINE, ITRACONAZOLE, TOPIRAMATE, MODAFINIL, 5-FLUOROURACIL, HYDROCHLOROTHAZIDE, ACETAMINOPHEN, ASPIRIN, FLURBIPROFEN, PHENYTOIN AND IBUPROFEN