(19)

(11)

EP 1 631 309 A2

(12)

(88) Date of publication A3: 24.03.2005 (43) Date of publication: 08.03.2006 Bulletin 2006/10 (21) Application number: 03731305.3 (22) Date of filing: 16.05.2003

(51) International Patent Classification (IPC):  A61K 38/02(1995.01) C07K 2/00(1995.01) A61K 38/08(1995.01) C07K 7/06(1985.01) (86) International application number: PCT/US2003/016070 (87) International publication number: WO 2004/103266 (02.12.2004 Gazette 2004/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (71) Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Stanford, California 94305 (US)	(72) Inventors: MOCHLY-ROSEN, Daria Menlo Park, CA 94025 (US) KENDIG, Joan, J. Campbell, CA 95008 (US) SWEITZER, Sarah, M. Vallejo, CA 94590 (US) (74) Representative: Vossius & Partner  Siebertstrasse 4 81675 München 81675 München (DE)