(19)

(11)

EP 1 631 311 A2

(12)

(88) Date of publication A3: 22.12.2005 (43) Date of publication: 08.03.2006 Bulletin 2006/10 (21) Application number: 03819151.6 (22) Date of filing: 10.12.2003

(51) International Patent Classification (IPC):  A61K 39/395(1985.01) (86) International application number: PCT/US2003/039599 (87) International publication number: WO 2005/060368 (07.07.2005 Gazette 2005/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (71) Applicant: MILLENNIUM PHARMACEUTICALS, INC. Cambridge, MA 02139-4169 (US)	(72) Inventors: O'KEEFE, Theresa Waltham, MA 02453 (US) PONATH, Paul San Francisco, CA 94114 (US) (74) Representative: Williams, Gareth Owen  Marks & Clerk 66-68 Hills Road Cambridge CB2 1LA Cambridge CB2 1LA (GB)