(19)

(11)

EP 1 631 348 A2

(12)

(88) Date of publication A3: 10.03.2005 (43) Date of publication: 08.03.2006 Bulletin 2006/10 (21) Application number: 04754797.1 (22) Date of filing: 09.06.2004

(51) International Patent Classification (IPC):  A61N 1/362(1985.01) (86) International application number: PCT/US2004/018298 (87) International publication number: WO 2004/110307 (23.12.2004 Gazette 2004/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 09.06.2003 US 477086 P (71) Applicant: The University of Cincinnati Cincinnati, Ohio 45267-0558 (US)	(72) Inventor: MELVIN, David, Boyd Loveland, OH 45140 (US) (74) Representative: Findlay, Alice Rosemary  Lloyd Wise Commonwealth House, 1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)