(19)

(11)

EP 1 631 682 A1

(12)

(43) Date of publication: 08.03.2006 Bulletin 2006/10 (21) Application number: 04736172.0 (22) Date of filing: 04.06.2004

(51) International Patent Classification (IPC):  C12Q 1/68(1980.01) C12N 15/12(1990.01) C12N 15/11(1990.01) G06F 19/00(1995.01) (86) International application number: PCT/SG2004/000166 (87) International publication number: WO 2004/108964 (16.12.2004 Gazette 2004/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 04.06.2003 US 475508 P (71) Applicant: Agency for Science, Technology and Research Singapore 138668 (SG)	(72) Inventors: REN, Ee, Chee Singapore 279301 (SG) NEO, Soek, Ying Singapore 248777 (SG) (74) Representative: Goodfellow, Hugh Robin et al Carpmaels & Ransford, 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)