(19)

(11)

EP 1 634 077 A2

(12)

(88) Date of publication A3: 21.04.2005 (43) Date of publication: 15.03.2006 Bulletin 2006/11 (21) Application number: 04753628.9 (22) Date of filing: 28.05.2004

(51) International Patent Classification (IPC):  G01N 33/543(1985.01) (86) International application number: PCT/US2004/016828 (87) International publication number: WO 2004/108888 (16.12.2004 Gazette 2004/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 30.05.2003 US 474574 P (71) Applicant: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM Austin, TX 78701 (US)	(72) Inventors: KLEBE, Robert, J. Helotes, TX 78023 (US) COX, James W. University of Texas Houston, TX 77054 (US) (74) Representative: Leissler-Gerstl, Gabriele et al Eisenführ, Speiser & Partner Postfach 31 02 60 80102 München 80102 München (DE)