(19)

(11)

EP 1 636 205 A1

(12)

(43) Date of publication: 22.03.2006 Bulletin 2006/12 (21) Application number: 04736303.1 (22) Date of filing: 08.06.2004

(51) International Patent Classification (IPC):  C07D 401/06(1990.01) C07D 213/75(1985.01) C07D 401/12(1990.01) A61K 31/44(1985.01) C07D 213/74(1985.01) C07D 401/04(1990.01) A61K 31/4427(2000.01) A61P 3/10(2000.01) (86) International application number: PCT/DK2004/000391 (87) International publication number: WO 2004/111031 (23.12.2004 Gazette 2004/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 12.06.2003 DK 200300879 13.06.2003 US 478526 P (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: CORNELIS DE JONG, Johannes DK-2880 Bagsv rd (DK) JACOBSEN, Poul DK-3550 Slangerup (DK) EBDRUP, S ren DK-4000 Roskilde (DK) (74) Representative: Noergaard, Torsten et al c/o Novo Nordisk A/S Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)