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(11)

EP 1 636 269 A2

(12)

(88) Date of publication A3: 14.07.2005 (43) Date of publication: 22.03.2006 Bulletin 2006/12 (21) Application number: 04736511.9 (22) Date of filing: 10.06.2004

(51) International Patent Classification (IPC):  C07K 16/14(1995.01) C07K 14/38(1995.01) C12N 5/10(1990.01) G01N 33/50(1980.01) A61K 39/395(1985.01) C12N 15/11(1990.01) A61K 38/00(1995.01) (86) International application number: PCT/DK2004/000407 (87) International publication number: WO 2004/108765 (16.12.2004 Gazette 2004/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 10.06.2003 DK 200300862 11.06.2003 US 477355 P 26.06.2003 DK 200300968 26.06.2003 US 482451 P (71) Applicant: Ace Biosciences A/S 5220 Odense S (DK)

(72) Inventors: ROCHE, Andrew DK-5792 Arslev (DK) HANSEN, Martin, Chr. DK-5250 Odense SV (DK) VILLSEN, Inge, D. DK-5220 Odense SO (DK) SCHROTZ-KING, Petra DK-5260 Odense S (DK) HENNINGSEN, Jeanette DK-5220 Odense SO (DK) JORGENSEN, Trine, Louise, Lund DK-5220 Odense SO (DK) (74) Representative: HOEIBERG A/S  European Patent & Trademark Attorneys St. Kongensgade 59 A DK-1264 Copenhagen K DK-1264 Copenhagen K (DK)