(19)

(11)

EP 1 638 942 A1

(12)

(43) Date of publication: 29.03.2006 Bulletin 2006/13 (21) Application number: 04739704.7 (22) Date of filing: 08.06.2004

(51) International Patent Classification (IPC):  C07D 233/22(1985.01) C07D 401/06(1990.01) C07D 401/14(1990.01) C07D 403/12(1990.01) C07D 405/14(1990.01) C07D 413/12(1990.01) C07D 491/10(1985.01) A61K 31/4178(2000.01) C07D 233/36(1985.01) C07D 401/12(1990.01) C07D 403/06(1990.01) C07D 405/12(1990.01) C07D 409/12(1990.01) C07D 417/12(1990.01) A61K 31/4164(2000.01) (86) International application number: PCT/EP2004/006176 (87) International publication number: WO 2005/003097 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 17.06.2003 US 479351 P (71) Applicant: F. HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventors: HALEY, Gregory, Jay San Diego, CA 92129 (US) KONG, Norman West Caldwell, NJ 07006 (US) LIU, Emily, Aijun Nutley, NJ 07110 (US) SIMONSEN, Klaus, B. San Diego, CA 92122 (US) VU, Binh, Thanh North Caldwell, NJ 07006 (US) WEBBER, Stephen, Evan San Diego, CA 92122 (US) (74) Representative: Klein, Thomas et al F. Hoffmann-La Roche AG Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)