(19)

(11)

EP 1 638 959 A1

(12)

(43) Date of publication: 29.03.2006 Bulletin 2006/13 (21) Application number: 04736513.5 (22) Date of filing: 10.06.2004

(51) International Patent Classification (IPC):  C07D 405/12(1990.01) A61K 31/445(1985.01) C07D 405/14(1990.01) (86) International application number: PCT/EP2004/006278 (87) International publication number: WO 2005/003122 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 19.06.2003 WO PCT/EP03/50237 (71) Applicant: JANSSEN PHARMACEUTICA N.V. 2340 Beerse (BE)	(72) Inventors: BOSMANS, Jean-Paul René Marie André 2340 Beerse (BE) GIJSEN, Henricus Jacobus Maria 2340 Beerse (BE) MEVELLEC, Laurence Anne, Janssen-Cilag 92787 Issy-les-Moulineaux Cedex 9 (FR) (74) Representative: Verberckmoes, Filip Gerard  Janssen Pharmaceutica N.V., J&J Patent Law Department, Turnhoutseweg 30 2340 Beerse 2340 Beerse (BE)