(19)

(11)

EP 1 639 124 A2

(12)

(88) Date of publication A3: 14.04.2005 (43) Date of publication: 29.03.2006 Bulletin 2006/13 (21) Application number: 04737905.2 (22) Date of filing: 29.06.2004

(51) International Patent Classification (IPC):  C12Q 1/34(1980.01) C12Q 1/48(1980.01) C12Q 1/42(1980.01) C12Q 1/44(1980.01) (86) International application number: PCT/CA2004/000966 (87) International publication number: WO 2005/003377 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 01.07.2003 US 483636 P 01.04.2004 US 558099 P (71) Applicant: McMASTER UNIVERSITY Hamilton Ontario L8S 4L8 (CA)	(72) Inventors: LI, Yingfu Dundas, Ontario L9H 6Y2 (CA) NUTIU, Razvan Hamilton, Ontario L8S 1H2 (CA) (74) Representative: Gates, Marie Christina Esther et al Tomkins & Co. 5 Dartmouth Road Dublin 6 Dublin 6 (IE)