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(11)

EP 1 641 411 A1

(12)

(43) Date of publication: 05.04.2006 Bulletin 2006/14 (21) Application number: 04754440.8 (22) Date of filing: 07.06.2004

(51) International Patent Classification (IPC):  A61D 19/02(1990.01) A61B 17/43(1990.01) C12N 5/06(1990.01) B01L 3/00(1968.09) (86) International application number: PCT/US2004/017829 (87) International publication number: WO 2004/108011 (16.12.2004 Gazette 2004/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 06.06.2003 US 476664 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN Ann Arbor, MI 48109-8202 (US)	(72) Inventors: TAKAYAMA, Shuichi Ann Arbor, MI 48105 (US) SMITH, Gary, D. Ann Arbor, MI 48104 (US) SUH, Ronald Ann Arbor, MI 48103 (US) (74) Representative: Maggs, Michael Norman et al Kilburn & Strode 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)