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EP 1 641 776 A1

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(43) Date of publication: 05.04.2006 Bulletin 2006/14 (21) Application number: 04730993.5 (22) Date of filing: 04.05.2004

(51) International Patent Classification (IPC):  C07D 401/12(1990.01) A61K 31/4709(2000.01) C07D 401/14(1990.01) A61P 9/00(2000.01) (86) International application number: PCT/EP2004/004717 (87) International publication number: WO 2004/099180 (18.11.2004 Gazette 2004/47)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 08.05.2003 WO PCT/EP03/04811 (71) Applicant: Actelion Pharmaceuticals Ltd. 4123 Allschwil (CH)

(72) Inventors: AISSAOUI, Hamed F-68840 Pulversheim (FR) BINKERT, Christoph CH-4054 Basel (CH) CLOZEL, Martine CH-4102 Binningen (CH) MATHYS, Boris CH-4622 Egerkingen (CH) MÜLLER, Claus F-68220 Hegenheim (FR) NAYLER, Oliver CH-4144 Arlesheim (CH) SCHERZ, Michael CH-4107 Ettingen (CH) VELKER, Jorg 68330 Huningue (FR) WELLER, Thomas CH-4102 Binningen (CH) (74) Representative: Ruhlmann, Eric  Actelion Pharmaceuticals Ltd Gewerbestrasse 16 4123 Allschwil 4123 Allschwil (CH)