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EP 1 641 803 A1

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(43) Date of publication: 05.04.2006 Bulletin 2006/14 (21) Application number: 04736524.2 (22) Date of filing: 10.06.2004

(51) International Patent Classification (IPC):  C07D 495/04(1985.01) A61P 9/00(2000.01) A61K 31/495(1985.01) (86) International application number: PCT/GB2004/002454 (87) International publication number: WO 2004/111057 (23.12.2004 Gazette 2004/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 11.06.2003 US 477518 P 11.06.2003 GB 0315950 (71) Applicant: Xention Discovery Limited Pampisford Cambridge CB2 4EF (GB)

(72) Inventors: FORD, John Huntingdon PE28 9BN (GB) PALMER, Nicholas, John Cambridge CB1 3HJ (GB) ATHERALL, John Frederick Saffron Walden, Essex CB10 2LL (GB) MADGE, David John East Grinstead, West Sussex RH19 4JZ (GB) SHERBORNE, Brad Stirling FKB 2JT (GB) BUSHFIELD, Mark Cambridge CB1 6DY (GB) STEVENS, Edward Benedict Newmarket, Suffolk CB8 8HW (GB) (74) Representative: Chapman, Paul William et al Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)