| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
|
| (30) |
Priority: |
19.05.2003 JP 2003141124
|
| (43) |
Date of publication of application: |
|
05.04.2006 Bulletin 2006/14 |
| (73) |
Proprietor: AJINOMOTO CO., INC. |
|
Chuo-ku
Tokyo 104-8315 (JP) |
|
| (72) |
Inventors: |
|
- SHIBAHARA, Susumu,c/o AJINOMOTO CO., INC.,
Kawasaki-shi,
Kanagawa 210-8681 (JP)
- SAKAI, Ryosei,c/o AJINOMOTO CO., INC.,
Kawasaki-shi,
Kanagawa 210-8681 (JP)
|
| (74) |
Representative: Nicholls, Kathryn Margaret et al |
|
Mewburn Ellis LLP
33 Gutter Lane
London
EC2V 8AS
London
EC2V 8AS (GB) |
| (56) |
References cited: :
EP-A- 1 609 375
WO-A2-03/015605
JP-A- 5 170 647
JP-A- 2002 504 510
|
WO-A2-00/51590
CN-A- 1 159 919
JP-A- 57 193 417
|
|
| |
|
|
- EGGERS E.D. ET AL: 'Mechanisms for the modulation of native glycine receptor channels
by ethanol' J. NEUROPHYSIOL vol. 91, no. 6, June 2004, pages 2685 - 2695, XP002981827
- INOUE: 'Changes in tongue reflex responses during sleep' vol. 33, no. 1, 11 July 2003,
pages 57 - 58, XP002981832
- DUTSCHMANN M. ET AL: 'Trigeminal reflex regulation of the glottis depends on central
glycinergic inhibition in the rat' AM J PHYSIOL REGULATORY INTERGRATIVE COMP PHYSIOL
vol. 282, no. 4, 2002, pages R999 - R1005, XP002981833
- KUBIN L. ET AL: 'Suppression of Hypoglossal motoneurons during the carbachol-induced
antonia of REM sleep is not caused by fast synaptic inhibition' BRAIN RES. vol. 611,
no. 2, 1993, pages 300 - 312, XP000609478
- HORNER R.L.: 'Is there a rationale in modulating brainstem neurons in obstructive
sleep apnea and is it clinically relevant?' SLEEP vol. 23, no. 4, 2000, pages S179
- S181, XP002981834
- PATON J.F. ET AL: 'Central control of upper airway resistance regulating respiratory
airflow in mammals' J. ANAT. vol. 201, no. 4, 2002, pages 319 - 323, XP002981835
- MORRISON J.L. ET AL: 'Glycine at hypoglossal motor nucleus: genioglossus activity,
CO2 responses, and the additive effects of GABA' J. APPL. PHYSIOL. vol. 93, no. 5,
2002, pages 1786 - 1796, XP002981836
- SAARESRANTA T.: 'Hormones and Breathing' CHEST JOURNAL vol. 122, no. 6, 2002, pages
2165 - 2182, XP002981837
- YAMUY J. ET AL: 'Hypoglossal Motoneurons are postsynaptically inhibited during carbachol-induced
rapid eye movement sleep' NEUROSCIENCE vol. 94, no. 1, 1999, pages 11 - 15, XP000922754
- KODAMA T. ET AL: 'Changes in inhibitory amino acid release linked to pontine-induced
atonia: An in vivo microdialysis study' J. NEUROSCI. vol. 23, no. 4, February 2003,
pages 1548 - 1554, XP002981838
- LAI Y-Y. ETAL: 'Changes in monoamine release in the ventral horn and hypoglossal nucleus
linked to pontine inhibiton of muscle tone: An in vivo microdialysis study' THE JOURNAL
OF NEUROSCIENCE vol. 21, no. 8, 2001, pages 7384 - 7391, XP002981839
|
|
