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<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHUPLSK....................................</B001EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.15 (14 Jul 2008) -  2999001/0</B007EP></eptags></B000><B100><B110>1642589</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20121003</date></B140><B150><B151>W1</B151><B153>72</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>04733953.6</B210><B220><date>20040519</date></B220><B240><B241><date>20051208</date></B241><B242><date>20111005</date></B242></B240><B250>ja</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>2003141124</B310><B320><date>20030519</date></B320><B330><ctry>JP</ctry></B330></B300><B400><B405><date>20121003</date><bnum>201240</bnum></B405><B430><date>20060405</date><bnum>200614</bnum></B430><B450><date>20120829</date><bnum>201235</bnum></B450><B452EP><date>20120326</date></B452EP><B480><date>20121003</date><bnum>201240</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  31/198       20060101AFI20120227BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61P  11/00        20060101ALI20120227BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61P  43/00        20060101ALI20120227BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A23L   1/30        20060101ALI20120227BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A23K   1/16        20060101ALI20120227BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>MITTEL ZUR PRÄVENTION/BEHANDLUNG VON SCHNARCHEN ODER ATEMSTÖRUNGEN IM SCHLAF</B542><B541>en</B541><B542>PREVENTIVES/REMEDIES FOR SNORE OR RESPIRATORY DISTURBANCES DURING SLEEP</B542><B541>fr</B541><B542>AGENTS PREVENTIFS/REMEDES POUR DES TROUBLES DU RONFLEMENT OU RESPIRATOIRES PENDANT LE SOMMEIL</B542></B540><B560><B561><text>EP-A- 1 609 375</text></B561><B561><text>WO-A2-00/51590</text></B561><B561><text>WO-A2-03/015605</text></B561><B561><text>CN-A- 1 159 919</text></B561><B561><text>JP-A- 5 170 647</text></B561><B561><text>JP-A- 57 193 417</text></B561><B561><text>JP-A- 2002 504 510</text></B561><B562><text>EGGERS E.D. ET AL: 'Mechanisms for the modulation of native glycine receptor channels by ethanol' J. NEUROPHYSIOL vol. 91, no. 6, June 2004, pages 2685 - 2695, XP002981827</text></B562><B562><text>INOUE: 'Changes in tongue reflex responses during sleep' vol. 33, no. 1, 11 July 2003, pages 57 - 58, XP002981832</text></B562><B562><text>DUTSCHMANN M. ET AL: 'Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat' AM J PHYSIOL REGULATORY INTERGRATIVE COMP PHYSIOL vol. 282, no. 4, 2002, pages R999 - R1005, XP002981833</text></B562><B562><text>KUBIN L. ET AL: 'Suppression of Hypoglossal motoneurons during the carbachol-induced antonia of REM sleep is not caused by fast synaptic inhibition' BRAIN RES. vol. 611, no. 2, 1993, pages 300 - 312, XP000609478</text></B562><B562><text>HORNER R.L.: 'Is there a rationale in modulating brainstem neurons in obstructive sleep apnea and is it clinically relevant?' SLEEP vol. 23, no. 4, 2000, pages S179 - S181, XP002981834</text></B562><B562><text>PATON J.F. ET AL: 'Central control of upper airway resistance regulating respiratory airflow in mammals' J. ANAT. vol. 201, no. 4, 2002, pages 319 - 323, XP002981835</text></B562><B562><text>MORRISON J.L. ET AL: 'Glycine at hypoglossal motor nucleus: genioglossus activity, CO2 responses, and the additive effects of GABA' J. APPL. PHYSIOL. vol. 93, no. 5, 2002, pages 1786 - 1796, XP002981836</text></B562><B562><text>SAARESRANTA T.: 'Hormones and Breathing' CHEST JOURNAL vol. 122, no. 6, 2002, pages 2165 - 2182, XP002981837</text></B562><B562><text>YAMUY J. ET AL: 'Hypoglossal Motoneurons are postsynaptically inhibited during carbachol-induced rapid eye movement sleep' NEUROSCIENCE vol. 94, no. 1, 1999, pages 11 - 15, XP000922754</text></B562><B562><text>KODAMA T. ET AL: 'Changes in inhibitory amino acid release linked to pontine-induced atonia: An in vivo microdialysis study' J. NEUROSCI. vol. 23, no. 4, February 2003, pages 1548 - 1554, XP002981838</text></B562><B562><text>LAI Y-Y. ETAL: 'Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibiton of muscle tone: An in vivo microdialysis study' THE JOURNAL OF NEUROSCIENCE vol. 21, no. 8, 2001, pages 7384 - 7391, XP002981839</text></B562><B565EP><date>20090828</date></B565EP></B560></B500><B700><B720><B721><snm>SHIBAHARA, Susumu,c/o AJINOMOTO CO., INC.,</snm><adr><str>1-1, Suzuki-cho,
Kawasaki-ku,</str><city>Kawasaki-shi,
Kanagawa 210-8681</city><ctry>JP</ctry></adr></B721><B721><snm>SAKAI, Ryosei,c/o AJINOMOTO CO., INC.,</snm><adr><str>1-1, Suzuki-cho,
Kawasaki-ku,</str><city>Kawasaki-shi,
Kanagawa 210-8681</city><ctry>JP</ctry></adr></B721></B720><B730><B731><snm>AJINOMOTO CO., INC.</snm><iid>101236745</iid><irf>KMN/FP6339865</irf><adr><str>15-1, Kyobashi 1-chome,</str><city>Chuo-ku
Tokyo 104-8315</city><ctry>JP</ctry></adr></B731></B730><B740><B741><snm>Nicholls, Kathryn Margaret</snm><sfx>et al</sfx><iid>100029123</iid><adr><str>Mewburn Ellis LLP 
33 Gutter Lane</str><city>London
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