(19)

(11)

EP 1 644 411 A2

(12)

(88) Date of publication A3: 24.03.2005 (43) Date of publication: 12.04.2006 Bulletin 2006/15 (21) Application number: 04738978.8 (22) Date of filing: 05.07.2004

(51) International Patent Classification (IPC):  C07K 14/62(1995.01) A61P 5/50(2000.01) A61K 38/28(1995.01) (86) International application number: PCT/DK2004/000481 (87) International publication number: WO 2005/005477 (20.01.2005 Gazette 2005/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 11.07.2003 DK 200301065 16.07.2003 US 487683 P (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: JONASSEN, Ib DK-2500 Valby (DK) HAVELUND, Sven DK-2880 Bagsv rd (DK) KJELDSEN, Thomas, B rglund DK-2830 Virum (DK) RIBEL-MADSEN, Ulla DK-2830 Virum (DK) (74) Representative: Nielsen, Lars Balzer et al Novo Nordisk A/S Corporate Patents Novo Allée 2880 Bagsvaerd 2880 Bagsvaerd (DK)