(19)

(11)

EP 1 644 510 A2

(12)

(88) Date of publication A3: 09.06.2005 (43) Date of publication: 12.04.2006 Bulletin 2006/15 (21) Application number: 03817686.3 (22) Date of filing: 27.06.2003

(51) International Patent Classification (IPC):  C12N 15/87(1990.01) C12Q 1/68(1980.01) C07H 21/00(1974.07) A01H 9/00(1968.09) A01H 11/00(1968.09) (86) International application number: PCT/US2003/020381 (87) International publication number: WO 2005/010142 (03.02.2005 Gazette 2005/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (71) Applicants: Chromatin, Inc. Chicago, IL 60612 (US) The University of Chicago Chicago, IL 60637 (US)	(72) Inventors: MACH, Jennifer Chicago, IL 60641 (US) ZIELER, Helge Chicago, IL 60607 (US) JIN, RongGuan Chicago, IL 60637 (US) KEITH, Kevin Chicago, IL 60605 (US) COPENHAVER, Gregory Chapel Hill, NC 27514 (US) PREUSS, Daphne Chicago, IL 60637 (US) (74) Representative: Maschio, Antonio  D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)