(19)

(11)

EP 1 644 522 A2

(12)

(88) Date of publication A3: 14.07.2005 (43) Date of publication: 12.04.2006 Bulletin 2006/15 (21) Application number: 04740533.7 (22) Date of filing: 01.07.2004

(51) International Patent Classification (IPC):  C12Q 1/68(1980.01) (86) International application number: PCT/EP2004/007167 (87) International publication number: WO 2005/005661 (20.01.2005 Gazette 2005/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 02.07.2003 US 484465 P (71) Applicants: Novartis AG 4056 Basel (CH) BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL  Novartis Pharma GmbH 1230 Wien (AT) AT	(72) Inventor: LAVEDAN, Christian, Nicolas Potomac, MD 20854 (US) (74) Representative: von Sprecher, Georg et al Novartis AG Corporate Intellectual Property 4002 Basel 4002 Basel (CH)