(19)

(11)

EP 1 644 720 A2

(12)

(88) Date of publication A3: 15.12.2005 (43) Date of publication: 12.04.2006 Bulletin 2006/15 (21) Application number: 04776731.4 (22) Date of filing: 18.06.2004

(51) International Patent Classification (IPC):  G01N 21/45(1980.01) (86) International application number: PCT/US2004/019456 (87) International publication number: WO 2005/001445 (06.01.2005 Gazette 2005/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 19.06.2003 US 479732 P 13.04.2004 US 823389 (71) Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02139-4307 (US)

(72) Inventors: FANG-YEN, Christopher, M. Somerville, MA 02143 (US) POPESCU, Gabriel Brighton, MA (US) YANG, Changhuei Durham, NC 27708 (US) WAX, Adam, P. Chapel Hill, NC 27514 (US) DASARI, Ramachandra, R. Lexington, MA 02421-6334 (US) FELD, Michael, S. Newton, MA 02468 (US) (74) Representative: Greenwood, John David et al Graham Watt & Co LLP St Botolph's House 7-9 St Botolph's Road Sevenoaks Kent TN13 3AJ Sevenoaks Kent TN13 3AJ (GB)