(19)

(11)

EP 1 644 726 A1

(12)

(43) Date of publication: 12.04.2006 Bulletin 2006/15 (21) Application number: 04777704.0 (22) Date of filing: 08.07.2004

(51) International Patent Classification (IPC):  G01N 27/333(1990.01) (86) International application number: PCT/US2004/021770 (87) International publication number: WO 2005/008232 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 09.07.2003 US 485856 P (71) Applicant: Auburn University Auburn, AL 36849 (US)	(72) Inventors: BAKKER, Eric Auburn, AL 36830 (US) SHVAREV, Alexey Auburn, AL 36830 (US) (74) Representative: Price, Nigel John King  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)