(19)

(11)

EP 1 644 742 A2

(12)

(88) Date of publication A3: 13.01.2005 (43) Date of publication: 12.04.2006 Bulletin 2006/15 (21) Application number: 04717052.7 (22) Date of filing: 04.03.2004

(51) International Patent Classification (IPC):  G01N 33/74(1980.01) A61K 48/00(1990.01) A61P 1/00(2000.01) A61P 7/00(2000.01) A61P 11/00(2000.01) A61K 38/17(1995.01) A61P 9/00(2000.01) A61P 29/00(2000.01) A61P 25/00(2000.01) A61P 13/00(2000.01) (86) International application number: PCT/EP2004/002174 (87) International publication number: WO 2004/082567 (30.09.2004 Gazette 2004/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 17.03.2003 EP 03005470 (71) Applicant: Bayer HealthCare AG 51368 Leverkusen (DE)	(72) Inventors: GOLZ, Stefan 45326 Essen (DE) BRÜGGEMEIER, Ulf 42799 Leichlingen (DE) SUMMER, Holger 42113 Wuppertal (DE)