(19)

(11)

EP 1 646 372 A2

(12)

(88) Date of publication A3: 16.06.2005 (43) Date of publication: 19.04.2006 Bulletin 2006/16 (21) Application number: 04778119.0 (22) Date of filing: 14.07.2004

(51) International Patent Classification (IPC):  A61K 31/00(1985.01) A61K 31/519(2000.01) A61P 11/06(2000.01) A61K 31/553(2000.01) C12Q 1/68(1980.01) (86) International application number: PCT/US2004/022446 (87) International publication number: WO 2005/007144 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 14.07.2003 US 487072 P 05.04.2004 US 559611 P (71) Applicant: Decode Genetics EHF. 101 Reykjavik (IS)	(72) Inventors: HAKONARSON, Hakon IS-109 Reykjavik (IS) GURNEY, Mark, E. East Grand Rapids, MI 49506 (US) HALAPI, Eva IS-109 Reykjavik (IS) (74) Representative: A&P Arnason  Intellectual Property Group Efstaleiti 5 103 Reykjavik 103 Reykjavik (IS)