METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY

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EP 1 646 395 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	17.12.2014 Bulletin 2014/51

(45)	Mention of the grant of the patent:
	05.11.2014 Bulletin 2014/45

(21)	Application number: 00982308.9

(22)	Date of filing: 30.11.2000

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International Patent Classification (IPC):

A61K 38/00^(2006.01)
A61K 48/00^(2006.01)

A61K 38/16^(2006.01)

(86)	International application number:
	PCT/US2000/032590

(87)	International publication number:
	WO 2001/040438 (07.06.2001 Gazette 2001/23)

(54)	METHODS AND COMPOSITIONS FOR REGULATING LYMPHOCYTE ACTIVITY VERFAHREN UND ZUSAMMENSETZUNGEN ZUR REGULIERUNG DER LYMPHOZYTENAKTIVITÄT METHODES ET COMPOSITIONS PERMETTANT DE REGULER L'ACTIVITE DES LYMPHOCYTES

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

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Priority:

30.11.1999 US 168112 P

(43)	Date of publication of application:
	19.04.2006 Bulletin 2006/16

(73)	Proprietor: Curis, Inc.
	Lexington, MA 02421 (US)

(72)	Inventor:
	CROMPTON, Tessa London N4 2SP (US)

(74)	Representative: Horner, Martin Grenville et al
	Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS Glasgow G2 7JS (GB)

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References cited: :

WO-A-00/74706

WO-A1-98/30520

WILLIAMS K P ET AL: "FUNCTIONAL ANTAGONISTS OF SONIC HEDGEHOG REVEAL THE IMPORTANCE OF THE N TERMINUS FOR ACTIVITY" JOURNAL OF CELL SCIENCE, CAMBRIDGE UNIVERSITY PRESS, LONDON, GB, vol. 112, no. 22, 1999, pages 4405-4414, XP000918169 ISSN: 0021-9533
OUTRAM SUSAN V ET AL: "Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte" IMMUNITY, vol. 13, no. 2, August 2000 (2000-08), pages 187-197, XP002415875 ISSN: 1074-7613
EL ANDALOUSSI ABDELJABAR ET AL: "Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus" NATURE IMMUNOLOGY, vol. 7, no. 4, April 2006 (2006-04), pages 418-426, XP002415876 ISSN: 1529-2908
LIN J. ET AL.: 'Increased cAMP and cAMP-dependent protein kinase activity mediate anti-CD2 induced suppression of anti-CD3-driven interleukin-2 production and CD25 expression' vol. 63, September 1995, pages 175 - 187, XP002960939

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