| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
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| (30) |
Priority: |
21.07.2003 GB 0317009
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| (43) |
Date of publication of application: |
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19.04.2006 Bulletin 2006/16 |
| (60) |
Divisional application: |
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15154759.3 / 2955190 |
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16155811.9 / 3040340 |
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Proprietor: NuCana BioMed Limited |
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Edinburgh EH12 9RG (GB) |
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| (72) |
Inventor: |
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- McGUIGAN, Christopher
Whitchurch,
Cardiff CF4 2EH (GB)
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| (74) |
Representative: Atkinson, Jonathan David Mark |
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HGF Limited
1 City Walk Leeds LS11 9DX Leeds LS11 9DX (GB) |
| (56) |
References cited: :
WO-A-01/07454 WO-A1-99/37753 US-A1- 2003 109 697
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WO-A-01/07454 US-A1- 2003 109 697
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- LACKEY D B ET AL: "Enzyme-catalyzed therapeutic agent (ECTA) design: activation of
the antitumor ECTA compound NB1011 by thymidylate synthase" BIOCHEMICAL PHARMACOLOGY,
PERGAMON, OXFORD, GB, vol. 61, 2001, pages 179-189, XP002204184 ISSN: 0006-2952
- S.A. HARRIS ET AL.: "Synthesis and antiviral evaluation of phosphoramidate derivatives
of (E)-5-(2-bromovinyl)-2'-deoxyuridine" ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, vol.
12, 2001, pages 293-300, XP008037325
- WHALEN LISA J ET AL: "Synthesis and evaluation of phosphoramidate amino acid-based
inhibitors of sialyltransferases" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON,
ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/S0960-894X(02)00735-7, vol. 13, no. 2, 1 January
2003 (2003-01-01), pages 301-304, XP002495584 ISSN: 0960-894X
- JUODKA BENEDIKTAS ET AL: "Oligonucleotides and nucleotide-peptides. XXXVII. On the
mechanism of hydrolysis of uridylyl-(5' .fwdarw. N)-amino acids. Intramolecular catalysisby
the .alpha.-carboxyl group of amino acids" JOURNAL OF CARBOHYDRATES. NUCLEOSIDES NUCLEOTIDES,
MARCEL DEKKER, BASEL, CH, vol. 8, no. 6, 1 January 1981 (1981-01-01) , pages 519-535,
XP009099165 ISSN: 0094-0585
- MCGUIGAN C ET AL: "SYNTHESIS AND EVALUATION OF SOME MASKED PHOSPHATE ESTERS OF THE
ANTI-HERPESVIRUS DRUG 882C (NETIVUDINE) AS POTENTIAL ANTIVIRAL AGENTS" ANTIVIRAL CHEMISTRY
& CHEMOTHERAPY, BLACKWELL SCIENTIFIC PUBL., LONDON, GB, vol. 9, 1 January 1998 (1998-01-01),
pages 233-243, XP000943516 ISSN: 0956-3202
- JUODKA B ET AL: "Oligonucleotides and nucleotide-peptides. XXXIV. Synthesis and some
properties of complex nucleotidyl (oligonucleotidyl)-(P .fwdarw. N)-amino acids (peptides)
and their ethyl esters" JOURNAL OF CARBOHYDRATES. NUCLEOSIDES NUCLEOTIDES, MARCEL
DEKKER, BASEL, CH, vol. 6, no. 4, 1 January 1979 (1979-01-01) , pages 333-357, XP009099193
ISSN: 0094-0585
- D.M. LEHSTEN ET AL.: "An improved procedure for the synthesis of nucleoside amidates"
ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 6, 2002, pages 819-822, XP002584043
- D.C. REMY ET AL.: "Studies on fluorinated pyrimidines. XIV. The synthesis of derivatives
of 5-fluoro-2'-deoxyuridine 5'-phosphate and related compounds" J. ORG. CHEM., vol.
27, 1962, pages 2491-2500, XP002584044
- LACKEY D B ET AL: "Enzyme-catalyzed therapeutic agent (ECTA) design: activation of
the antitumor ECTA compound NB1011 by thymidylate synthase" BIOCHEMICAL PHARMACOLOGY,
PERGAMON, OXFORD, GB, vol. 61, 2001, pages 179-189, XP002204184 ISSN: 0006-2952
- S.A. HARRIS ET AL.: "Synthesis and antiviral evaluation of phosphoramidate derivatives
of (E)-5-(2-bromovinyl)-2'-deoxyuridine" ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, vol.
12, 2001, pages 293-300, XP008037325
- ABRAHAM T W ET AL: "Synthesis and biological activity of aromatic amino acid phosphoramidates
of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase
activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 39,
1 January 1996 (1996-01-01), pages 4569-4575, XP002147029, ISSN: 0022-2623, DOI: 10.1021/JM9603680
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