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(11)

EP 1 646 654 A1

(12)

(43) Date of publication: 19.04.2006 Bulletin 2006/16 (21) Application number: 04738989.5 (22) Date of filing: 08.07.2004

(51) International Patent Classification (IPC):  C07K 16/12(1995.01) C12N 15/13(1990.01) C12N 5/10(1990.01) G01N 33/577(1985.01) A61K 39/40(1985.01) C07K 16/46(1995.01) C12N 15/62(1990.01) G01N 33/569(1985.01) A61K 39/395(1985.01) (86) International application number: PCT/DK2004/000492 (87) International publication number: WO 2005/003174 (13.01.2005 Gazette 2005/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR (30) Priority: 08.07.2003 DK 200301044 11.07.2003 US 486647 P (71) Applicant: GENESTO A/S 2970 Horsholm (DK)	(72) Inventors: SORENSEN, Anders, Per DK-3400 Hillerod (DK) BENFIELD, Thomas, Lars DK-2100 Copenhagen O (DK) LUNDGREN, Jens, Dilling DK-2920 Charlottenlund (DK) KEMPE, Thomas, D. Sunnyvale, CA 94087 (US) (74) Representative: Hoeiberg, Susanne  Hoeiberg ApS, St. Kongensgade 59 B 1264 Copenhagen K 1264 Copenhagen K (DK)