(19)

(11)

EP 1 648 232 A2

(12)

(88) Date of publication A3: 26.05.2005 (43) Date of publication: 26.04.2006 Bulletin 2006/17 (21) Application number: 04778450.9 (22) Date of filing: 16.07.2004

(51) International Patent Classification (IPC):  A01N 43/40(1985.01) A61K 31/47(1985.01) C07J 31/00(1974.07) C07J 9/00(1974.07) A01N 43/42(1985.01) A61K 31/445(1985.01) C07J 41/00(1974.07) (86) International application number: PCT/US2004/022946 (87) International publication number: WO 2005/009361 (03.02.2005 Gazette 2005/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: HR LT LV (30) Priority: 17.07.2003 US 488056 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, Pennsylvania 19101 (US)	(72) Inventors: GARDNER, Margaret M. Philadelphia, PA 19101 (US) HURSTING, Marcie, J. Potomac, MD 20854 (US) TARKA, Elizabeth, A. King of Prussia, PA 19406 (US) VERME-GIBBONEY, Catherine N. Philadelphia, PA 19101 (US) (74) Representative: Hambleton, Bernadette Angelina et al GlaxoSmithKline C.I.P. (CN925.1) 980 Great West Road GB-Brentford, Middlesex TW8 9GS GB-Brentford, Middlesex TW8 9GS (GB)